What are Avocado soybean Unsaponifiables tablets?
Avocado soybean unsaponifiables (ASU) are natural vegetable extracts derived from avocado and soybean oils. ASU has been demonstrated to help with some of the symptoms of osteoarthritis and may even slow down the disease’s development. Avocado soybean unsaponifiables are safe and beneficial for persons with osteoarthritis, according to the Arthritis Foundation.
How Does ASU Work?
ASU is made up of one-third avocado and two-thirds soybean unsaponifiables, which are lipid components that can’t be made into soap due to their nature.
While the last portion of that definition may seem to be unimportant, it is thought that the unique composition of unsaponifiable is responsible for its health advantages.
Surprisingly, specialists are unsure which molecule in this mixture is the active agent; it might be a compound formed by a combination of chemicals.
The effects of ASU include a decrease in cartilage breakdown and an increase in cartilage repair.
ASU reduces inflammation, and it has been discovered to precisely reduce the inflammatory cells and proteins that contribute to cartilage breakdown in osteoarthritis.
What ASU for Arthritis Research Reveals
Even in significant proportions, eating avocado and soy does not produce enough unsaponifiable to alleviate osteoarthritis symptoms. The unsaponifiable part of the oil is just a tiny percentage of the total.
ASU’s impact on osteoarthritis, especially knee and hip osteoarthritis, has been studied in a variety of human research studies as well as several animal studies.
In terms of symptom relief, the results have been generally positive, and there have been no known side effects or safety concerns.
A six-month trial, for example, looked at the effects of ASU on women with temporomandibular joint osteoarthritis. When compared to people who did not take ASU, those who took it had less discomfort, had a higher quality of life and reported using fewer pain medicines such as nonsteroidal anti-inflammatory drugs (NSAIDs).
Three-year research monitored a group of hip osteoarthritis individuals. The group that took ASU saw somewhat less reduction of joint space breadth than the control group. Imaging tests are used to evaluate decreased joint space width, which is usually thought to be a sign of progressive osteoarthritis. During the trial, no difficulties with safety were discovered.
Experts believe that taking ASU as a preventative measure during the early stages of osteoarthritis may be useful.
Management of Osteoarthritis with the help of Avocado/Soybean Unsaponifiables
Osteoarthritis (OA) is a painful and life-altering disease that severely affects millions of Americans’ everyday activities and is one of the world’s most frequent causes of disability. Obesity is on the rise, and the world’s population is living longer, therefore the incidence of OA is predicted to skyrocket in the future decades, resulting in significant socioeconomic consequences. This study reviews existing pharmacological, nonpharmaceutical, and potential novel therapies for OA, focusing on the dietary supplement avocado/soybean unsaponifiables (ASU). ASU affects OA pathogenesis by blocking a variety of OA-related molecules and processes. By decreasing the production and activity of matrix metalloproteinases and enhancing tissue inhibitors of these catabolic enzymes, anticatabolic characteristics limit cartilage degeneration. ASU also inhibits fibrinolysis by increasing plasminogen activator inhibitor expression. By inhibiting inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor, ERK, and prostaglandin E2, anabolic characteristics enhance cartilage repair by promoting collagen and aggrecan production. Correcting growth factor aberrations, boosting TGF-, and reducing vascular endothelial growth factor (VEGF) in synovial fluid all have chondroprotective benefits. ASU also reduces cholesterol absorption and endogenous cholesterol production in chondrocytes, both of which are involved in reactive oxygen species disease. ASU decreases pain and stiffness while increasing joint function in the clinic, leading to less reliance on analgesics.